Abstract: A weight-reduction plan excessive in guar gum, a dietary fiber and a typical meals additive extracted from guar beans, limits irritation and delays the onset of a number of sclerosis in mouse fashions.
Supply: College of British Columbia
Diets excessive in guar gum, a typical meals additive and dietary fiber, restricted irritation and delayed the onset of a number of sclerosis (MS) signs in mice, in accordance with a brand new examine by members of the Division of Microbiology and Immunology College of British Columbia (UBC).
“The fast improve in autoimmune and inflammatory issues in industrialized nations in the previous few a long time means that dietary decisions are one environmental issue contributing to the incidence,” mentioned Dr. Lisa Osborne, senior researcher on the examine and assistant professor with UBC Microbiology and Immunology.
“Dietary fibers are sturdy modulators of immune responses and may management irritation in a variety of ailments, however they’re a really biochemically various household. Our examine offers us a clearer window into the potential of varied fiber sources in sustaining immune well being.”
Dr. Osborne and his colleagues uncovered teams of mice to a mixture of diets – a management 5 p.c cellulose fiber weight-reduction plan, a weight-reduction plan missing in dietary fiber, or a weight-reduction plan enriched (30%) with fiber in resistant starch, inulin, pectin, or guar gum. Quar gum was the one sort of fiber that considerably lowered MS-like signs.
Guar gum – guaran – is extracted from guar beans, and is commonly used as an additive to thicken and stabilize meals and animal feed, and in industrial purposes. India and Pakistan are main growers of the bean.
“Guar beans should not that widespread in western meals, and the gum just isn’t used at these excessive ranges as an additive within the west,” mentioned Naomi Fettig, first creator of the examine and PhD scholar with the Division of Microbiology and Immunology at UBC.
“Specialists have constantly mentioned that fiber is nice for you – and lots of sources of fiber are essential for immune well being – however little essential work has been performed to grasp how the physique responds to several types of fiber . It is thrilling that this explicit retailer is having such an influence.”
Within the US and Canada, the common every day consumption of fiber is 15 grams – present suggestions are double that at 30 grams. The beneficial values don’t keep in mind a particular fiber sort.
“It is perhaps troublesome to ingest guar beans on the doses we gave to mice,” mentioned Dr Osborne. “However a guar gum product, partially hydrated guar gum, is commercially accessible as a prebiotic.”
After the gum was damaged down by the mice’s microbiota, the ensuing molecules appeared to scale back the exercise and proliferation of a sort of CD4+ T cells, Th1 cells, which play a key position in activation of an autoimmune response. It’s that response that results in MS-like signs in mice.
The impact of fiber on Th1 cells was nonetheless largely unknown earlier than this examine, and these findings counsel that biochemical variations in fiber constructions can have an effect on totally different immune pathways.
Dr. Osborne and her lab now wish to discover the potential advantages for people – together with creating a extra detailed understanding of the molecular image, which may assist designing therapeutics that present the advantages of excessive guar gum meals in a extra sensible type.
About this weight-reduction plan and a number of sclerosis analysis information
Writer: Chris Balma
Supply: College of British Columbia
Contact: Chris Balma – College of British Columbia
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Authentic search: Open alternative.
“Inhibition of Th1 activation and differentiation by dietary guar gum reduces experimental autoimmune encephalomyelitis” by Lisa Osborne et al. Cell reviews
Inhibition of Th1 activation and differentiation by dietary guar gum attenuates experimental autoimmune encephalomyelitis
- Particular person dietary fiber sources have distinct results on T cell subsets
- The dietary fiber guar gum negatively impacts Th1 polarization and alters migratory capability
- Guar gum will increase short-chain fatty acids however doesn’t have an effect on regulatory T cells
- Guar gum supplementation considerably delays autoimmune neuroinflammation
Dietary fibers are sturdy modulators of immune responses that may forestall irritation within the context of a number of ailments.
Nonetheless, dietary fiber contains a biochemically various household of carbohydrates, and it’s nonetheless unknown how particular person fiber sources have an effect on immunity.
In a direct comparability of 4 totally different high-fiber diets, we show the potent potential of guar gum to delay illness and neuroinflammation in experimental autoimmune encephalomyelitis, a T-cell-mediated mouse mannequin of a number of sclerosis.
Guar gum-specific modifications to the microbiota are restricted, and illness safety seems to be unbiased of fiber-based will increase in short-chain fatty acid ranges or regulatory CD4+ T cell. As a substitute, CD4+ T cells of guar-supplemented mice are much less encephalitogenic as a consequence of lowered activation, proliferation, Th1 differentiation, and altered migratory capability.
These findings show specificity within the host’s response to fiber sources and outline a pathway of fiber-induced immunomodulation that protects in opposition to pathologic neuroinflammation.